LARP7 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Phenserine Tiomolibdate ion CAD106 Mito-4509 Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F)	Alzheimer's disease (AD)
CHRNB4	cholinergic receptor nicotinic beta 4 subunit	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation	Nicotine Dextromethorphan Galantamine Ethanol Pentolinium Levomethadyl Acetate Epibatidine
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2	Signaling by ERBB4 GABA receptor activation GABA receptor activation	Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Olanzapine Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Zolpidem Metharbital Chlordiazepoxide Amoxapine Adinazolam Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Flunitrazepam Bromazepam Clotiazepam Fludiazepam Prazepam Prazepam Quazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Adipiplon Stiripentol Etizolam Thiocolchicoside Muscimol Lormetazepam	Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GAR1	GAR1 ribonucleoprotein	Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
JMJD6	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	HDMs demethylate histones
LRRK2	leucine rich repeat kinase 2	PTK6 promotes HIF1A stabilization		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
MCUB	mitochondrial calcium uniporter dominant negative subunit beta	Mitochondrial calcium ion transport Processing of SMDT1
OSTC	oligosaccharyltransferase complex non-catalytic subunit
PAPSS1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	Transport and synthesis of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Signaling by BRAF and RAF fusions	Adenosine-5'-Diphosphate-2',3'-Vanadate Adenosine 5'-phosphosulfate Glycerin
PPA2	inorganic pyrophosphatase 2	Mitochondrial tRNA aminoacylation Pyrophosphate hydrolysis
PRPF40A	pre-mRNA processing factor 40 homolog A	mRNA Splicing - Major Pathway
PUF60	poly(U) binding splicing factor 60	mRNA Splicing - Major Pathway
RN7SK	RNA component of 7SK nuclear ribonucleoprotein
RRH	retinal pigment epithelium-derived rhodopsin homolog	G alpha (i) signalling events Opsins
SMS	spermine synthase	Metabolism of polyamines	Spermine	Snyder-Robinson syndrome
ZGRF1	zinc finger GRF-type containing 1

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