| ATN1 |
atrophin 1 |
- Regulation of PTEN gene transcription
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- Dentatorubropallidoluysian atrophy (DRPLA)
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| GFI1B |
growth factor independent 1B transcriptional repressor |
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| GSC |
goosecoid homeobox |
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| LGMN |
legumain |
- Trafficking and processing of endosomal TLR
- Vitamin D (calciferol) metabolism
- MHC class II antigen presentation
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| LOXL1 |
lysyl oxidase like 1 |
- Elastic fibre formation
- Crosslinking of collagen fibrils
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| LPA |
lipoprotein(a) |
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| MEOX2 |
mesenchyme homeobox 2 |
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| NDUFA4 |
NDUFA4 mitochondrial complex associated |
- TP53 Regulates Metabolic Genes
- Respiratory electron transport
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| OTX1 |
orthodenticle homeobox 1 |
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| PAXIP1 |
PAX interacting protein 1 |
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Nonhomologous End-Joining (NHEJ)
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| PDIA3 |
protein disulfide isomerase family A member 3 |
- ER-Phagosome pathway
- ER-Phagosome pathway
- Calnexin/calreticulin cycle
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
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| PPP2R5C |
protein phosphatase 2 regulatory subunit B'gamma |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Degradation of beta-catenin by the destruction complex
- Beta-catenin phosphorylation cascade
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- CTLA4 inhibitory signaling
- Platelet sensitization by LDL
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Misspliced GSK3beta mutants stabilize beta-catenin
- S33 mutants of beta-catenin aren't phosphorylated
- S37 mutants of beta-catenin aren't phosphorylated
- S45 mutants of beta-catenin aren't phosphorylated
- T41 mutants of beta-catenin aren't phosphorylated
- APC truncation mutants have impaired AXIN binding
- AXIN missense mutants destabilize the destruction complex
- Truncations of AMER1 destabilize the destruction complex
- RHO GTPases Activate Formins
- RAF activation
- Negative regulation of MAPK pathway
- Regulation of TP53 Degradation
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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- 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
- (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
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| PRNP |
prion protein |
- NCAM1 interactions
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
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- Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)
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| PSMC1 |
proteasome 26S subunit, ATPase 1 |
- Activation of NF-kappaB in B cells
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- ER-Phagosome pathway
- Cross-presentation of soluble exogenous antigens (endosomes)
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Vpu mediated degradation of CD4
- Vif-mediated degradation of APOBEC3G
- SCF(Skp2)-mediated degradation of p27/p21
- Degradation of beta-catenin by the destruction complex
- Downstream TCR signaling
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Separation of Sister Chromatids
- FCERI mediated NF-kB activation
- Autodegradation of the E3 ubiquitin ligase COP1
- Regulation of ornithine decarboxylase (ODC)
- ABC-family proteins mediated transport
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Degradation of DVL
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Hedgehog ligand biogenesis
- Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Regulation of RAS by GAPs
- TNFR2 non-canonical NF-kB pathway
- NIK - noncanonical NF-kB signaling
- Defective CFTR causes cystic fibrosis
- MAPK6/MAPK4 signaling
- UCH proteinases
- Ub-specific processing proteases
- CDT1 association with the CDC6:ORC:origin complex
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- G2/M Checkpoints
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Ubiquitin-dependent degradation of Cyclin D
- The role of GTSE1 in G2/M progression after G2 checkpoint
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Regulation of PTEN stability and activity
- Neddylation
- Regulation of expression of SLITs and ROBOs
- Interleukin-1 signaling
- Negative regulation of NOTCH4 signaling
- Antigen processing: Ubiquitination & Proteasome degradation
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| SERPINA1 |
serpin family A member 1 |
- Platelet degranulation
- COPII-mediated vesicle transport
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Cargo concentration in the ER
- Neutrophil degranulation
- Post-translational protein phosphorylation
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- Zinc
- 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol
- Beta-Mercaptoethanol
- Recombinant alpha 1-antitrypsin
- Copper
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- Alpha-1-antitrypsin (A1AT) deficiency
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| SERPINA5 |
serpin family A member 5 |
- Intrinsic Pathway of Fibrin Clot Formation
- Common Pathway of Fibrin Clot Formation
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- Urokinase
- Drotrecogin alfa
- Tifuvirtide
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| SOD3 |
superoxide dismutase 3 |
- Detoxification of Reactive Oxygen Species
- Detoxification of Reactive Oxygen Species
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| ST3GAL3 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
- Pre-NOTCH Processing in Golgi
- Keratan sulfate biosynthesis
- Defective ST3GAL3 causes MCT12 and EIEE15
- Sialic acid metabolism
- Lewis blood group biosynthesis
- Termination of O-glycan biosynthesis
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- Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
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| TOP3B |
DNA topoisomerase III beta |
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| TRIP13 |
thyroid hormone receptor interactor 13 |
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| XCL1 |
X-C motif chemokine ligand 1 |
- Chemokine receptors bind chemokines
- G alpha (q) signalling events
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