FBLN5 and SOD3

Number of citations of the paper that reports this interaction (PubMedID 15528465)
43

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		FBLN5	SOD3
Description		fibulin 5	superoxide dismutase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Region Extracellular Space Nucleus Golgi Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals	Response To Hypoxia Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Response To Copper Ion Oxidation-reduction Process
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Diastolic blood pressure ( 30578418) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)	Blood protein levels ( 30072576 29875488) Major depressive disorder ( 23377640)
Interacting Genes		21 interacting genes: ATN1 GFI1B GSC LGMN LOXL1 LPA MEOX2 NDUFA4 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1	2 interacting genes: FBLN5 SGTA
Entrez ID		10516	6649
HPRD ID		05204	01708
Ensembl ID		ENSG00000140092	ENSG00000109610
Uniprot IDs		A0A024R6G3 Q9UBX5	A0A140VJU8 P08294
PDB IDs			2JLP
Enriched GO Terms of Interacting Partners?
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