| A2M |
alpha-2-macroglobulin |
- Platelet degranulation
- Intrinsic Pathway of Fibrin Clot Formation
- Degradation of the extracellular matrix
- Rho GTPase cycle
- HDL assembly
|
- Becaplermin
- Cisplatin
- Bacitracin
- Zinc
- Ocriplasmin
|
|
| ACAN |
aggrecan |
- Degradation of the extracellular matrix
- Degradation of the extracellular matrix
- Keratan sulfate biosynthesis
- Keratan sulfate degradation
- ECM proteoglycans
- Defective CHST6 causes MCDC1
- Defective ST3GAL3 causes MCT12 and EIEE15
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
|
|
- Spondyloepiphyseal dysplasia, Kimberley type
- Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
|
| ADRA2B |
adrenoceptor alpha 2B |
- Adrenoceptors
- Adrenaline signalling through Alpha-2 adrenergic receptor
- G alpha (i) signalling events
- G alpha (z) signalling events
|
- Amphetamine
- Bethanidine
- Ziprasidone
- Cabergoline
- Ropinirole
- Etomidate
- Olanzapine
- Clozapine
- Norepinephrine
- Phenylpropanolamine
- Loxapine
- Pramipexole
- Prazosin
- Chlorpromazine
- Brimonidine
- Nortriptyline
- Amoxapine
- Clonidine
- Lisuride
- Guanabenz
- Epinephrine
- Ergotamine
- Tizanidine
- Apomorphine
- Trimipramine
- Risperidone
- Tolazoline
- Fenoldopam
- Dobutamine
- Phenoxybenzamine
- Maprotiline
- Oxymetazoline
- Apraclonidine
- Guanfacine
- Ergoloid mesylate
- Carvedilol
- Doxepin
- Desipramine
- Pergolide
- Bromocriptine
- Quetiapine
- Aripiprazole
- Paliperidone
- Ephedra
- Mephentermine
- Yohimbine
- Methotrimeprazine
- Methamphetamine
- Dronedarone
- Rotigotine
- OPC-28326
- Epicept NP-1
- Mianserin
- Asenapine
- Droxidopa
- Esmirtazapine
- Xylometazoline
- Levonordefrin
- Dosulepin
- Etoperidone
- Cirazoline
- Setiptiline
- Tiapride
|
|
| FAM32A |
family with sequence similarity 32 member A |
|
|
|
| FURIN |
furin, paired basic amino acid cleaving enzyme |
- Signaling by NODAL
- Collagen degradation
- Collagen degradation
- Elastic fibre formation
- Activation of Matrix Metalloproteinases
- Removal of aminoterminal propeptides from gamma-carboxylated proteins
- NGF processing
- Synthesis and processing of ENV and VPU
- Signaling by PDGF
- Pre-NOTCH Processing in Golgi
- TGF-beta receptor signaling activates SMADs
- Uptake and function of anthrax toxins
- Formation of the cornified envelope
- Assembly of active LPL and LIPC lipase complexes
- CD163 mediating an anti-inflammatory response
- Amyloid fiber formation
|
|
|
| JAML |
junction adhesion molecule like |
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Cell surface interactions at the vascular wall
|
|
|
| TPSAB1 |
tryptase alpha/beta 1 |
- Activation of Matrix Metalloproteinases
|
- Amido Phenyl Pyruvic Acid
- 4-PIPERIDIN-4-YLBUTANAL
- [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE
- 1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine
- 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine
- (5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidine]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone
|
|
| VCAN |
versican |
- A tetrasaccharide linker sequence is required for GAG synthesis
- Chondroitin sulfate biosynthesis
- Dermatan sulfate biosynthesis
- CS/DS degradation
- ECM proteoglycans
- Defective B4GALT7 causes EDS, progeroid type
- Defective B3GAT3 causes JDSSDHD
- Defective CHST3 causes SEDCJD
- Defective CHST14 causes EDS, musculocontractural type
- Defective CHSY1 causes TPBS
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Defective B3GALT6 causes EDSP2 and SEMDJL1
- Post-translational protein phosphorylation
|
|
- Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
|
| VEGFA |
vascular endothelial growth factor A |
- Platelet degranulation
- Regulation of gene expression by Hypoxia-inducible Factor
- Signaling by VEGF
- VEGF ligand-receptor interactions
- VEGF binds to VEGFR leading to receptor dimerization
- Interleukin-4 and Interleukin-13 signaling
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
|
- Bevacizumab
- Minocycline
- Gliclazide
- Carvedilol
- Ranibizumab
- Pidolic Acid
- Tromethamine
- Vandetanib
- ABT-510
- VEGF-AS
- Dalteparin
- Aflibercept
- Chondroitin sulfate
|
|