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ADAMTS1

Description ADAM metallopeptidase with thrombospondin type 1 motif 1
Image
GO Annotations Cellular Component
  • Basement Membrane
  • Cytoplasmic Vesicle
  • Collagen-containing Extracellular Matrix
Molecular Function
  • Metalloendopeptidase Activity
  • Heparin Binding
  • Metallopeptidase Activity
  • Zinc Ion Binding
Biological Process
  • Ovulation From Ovarian Follicle
  • Kidney Development
  • Proteolysis
  • Integrin-mediated Signaling Pathway
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Angiogenesis
  • Heart Trabecula Formation
  • Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
  • Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
  • Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways
  • Degradation of the extracellular matrix
  • Defective B3GALTL causes Peters-plus syndrome (PpS)
  • O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS
  • Alzheimer's disease (late onset) ( 30820047)
  • Blood protein levels ( 28240269)
  • Cerebrospinal fluid neurofilament light levels ( 31930058)
  • Health literacy ( 31250787)
  • Metabolite levels ( 23823483)
Interacting Genes 9 interacting genes: A2M ACAN ADRA2B FAM32A FURIN JAML TPSAB1 VCAN VEGFA
Entrez ID 9510
HPRD ID 05530
Ensembl ID ENSG00000154734
Uniprot IDs B2RB33 Q9UHI8
PDB IDs 2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025

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