Pulmonary - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
TGFB2 and VTN	transforming growth factor beta 2	vitronectin	Platelet degranulation Molecules associated with elastic fibres ECM proteoglycans	Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade		Abciximab Zinc Copper	Graft-versus-host disease Allograft rejection
THRA and AKAP13	thyroid hormone receptor alpha	A-kinase anchoring protein 13	Nuclear Receptor transcription pathway	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid Eprotirome NRP409
THRA and NR0B2	thyroid hormone receptor alpha	nuclear receptor subfamily 0 group B member 2	Nuclear Receptor transcription pathway	Nuclear Receptor transcription pathway	Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid Eprotirome NRP409
TLE3 and TAOK2	TLE family member 3, transcriptional corepressor	TAO kinase 2	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression			Dexfosfoserine
TNFRSF1A and ATF6	TNF receptor superfamily member 1A	activating transcription factor 6	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling	ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes	6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One	Pseudoephedrine	Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
SYMPK and RIN3	symplekin	Ras and Rab interactor 3	Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	RAB GEFs exchange GTP for GDP on RABs
PICALM and PELI2	phosphatidylinositol binding clathrin assembly protein	pellino E3 ubiquitin protein ligase family member 2	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MAD1L1 and CCHCR1	mitotic arrest deficient 1 like 1	coiled-coil alpha-helical rod protein 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
MAD1L1 and USP15	mitotic arrest deficient 1 like 1	ubiquitin specific peptidase 15	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
MFHAS1 and RHBDD1	malignant fibrous histiocytoma amplified sequence 1	rhomboid domain containing 1
MFHAS1 and EGLN2	malignant fibrous histiocytoma amplified sequence 1	egl-9 family hypoxia inducible factor 2		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha		Vitamin C Roxadustat
MFHAS1 and RPAP3	malignant fibrous histiocytoma amplified sequence 1	RNA polymerase II associated protein 3
MFHAS1 and STN1	malignant fibrous histiocytoma amplified sequence 1	STN1 subunit of CST complex		Telomere C-strand synthesis initiation
MFHAS1 and VGLL4	malignant fibrous histiocytoma amplified sequence 1	vestigial like family member 4
HDAC4 and HDAC7	histone deacetylase 4	histone deacetylase 7	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX2 regulates chondrocyte maturation RUNX3 regulates p14-ARF	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription	Zinc Belinostat Romidepsin Panobinostat N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide Belinostat Panobinostat	Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
RIN3 and PLB1	Ras and Rab interactor 3	phospholipase B1	RAB GEFs exchange GTP for GDP on RABs	Acyl chain remodelling of PC Retinoid metabolism and transport
CEP70 and KANSL1	centrosomal protein 70	KAT8 regulatory NSL complex subunit 1	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	HATs acetylate histones
SOX4 and TERT	SRY-box transcription factor 4	telomerase reverse transcriptase	Deactivation of the beta-catenin transactivating complex	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex		Zidovudine Grn163l Tertomotide		Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
HEY1 and HEY2	hes related family bHLH transcription factor with YRPW motif 1	hes related family bHLH transcription factor with YRPW motif 2	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
A2M and ADAM19	alpha-2-macroglobulin	ADAM metallopeptidase domain 19	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly	Invadopodia formation	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin

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