SYMPK and RIN3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		SYMPK	RIN3
Description		symplekin	Ras and Rab interactor 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Nuclear Stress Granule	Early Endosome Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Export From Nucleus Cell Adhesion MRNA 3'-end Processing Negative Regulation Of Protein Binding Positive Regulation Of Protein Dephosphorylation	Endocytosis Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Colon cancer ( 28295283) Colorectal cancer ( 28295283) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Breast cancer ( 25751625 29059683) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Dialysis-related mortality ( 21546767) Eosinophil counts ( 27863252) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Granulocyte count ( 27863252) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Paget's disease ( 21623375) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30224653) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 27863252)
Interacting Genes		7 interacting genes: CSTF2 HSF1 HTT RIN3 TOP1 UBE2I YBX3	41 interacting genes: ASB3 ASB8 BIN1 CRK CRKL CSRP3 CYP2C8 CYP46A1 DOK3 EPS8L2 EZH2 GATA1 GRAP2 ID2 KCTD17 LCK MPEG1 MT2A PLB1 POLR3F PSMD9 RAB5A RAB5B RAB5C RABAC1 RGS2 RTL8B SPATA12 SPRY4 SUV39H1 SYMPK TENT5A TGM1 TM4SF19 TNFAIP1 TSC1 TSSK3 ZBTB24 ZNF639 ZNF655 ZNF71
Entrez ID		8189	79890
HPRD ID		09090	11494
Ensembl ID		ENSG00000125755	ENSG00000100599
Uniprot IDs		A0A024R0R6 Q92797	Q6NSK7 Q6ZRC2 Q86U22 Q8TB24
PDB IDs		3O2Q 3O2S 3O2T 3ODR 3ODS 4H3H 4H3K	3U23 4WCI
Enriched GO Terms of Interacting Partners?
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