CDH1 and HDAC1

Number of citations of the paper that reports this interaction (PubMedID 15388328)
19

Data Source:
HPRD (in vitro)

		CDH1	HDAC1
Description		cadherin 1	histone deacetylase 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse	Histone Deacetylase Complex Chromatin Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Sin3 Complex NuRD Complex Protein-containing Complex Neuronal Cell Body Sin3-type Complex
	Molecular Function	Calcium Ion Binding Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding P53 Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Krueppel-associated Box Domain Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding NF-kappaB Binding Repressing Transcription Factor Binding E-box Binding Promoter-specific Chromatin Binding
	Biological Process	Cell Morphogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Synapse Assembly Response To Toxic Substance Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Negative Regulation Of Cell Migration Neuron Projection Development Adherens Junction Organization Entry Of Bacterium Into Host Cell Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription, DNA-templated Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Methylation-dependent Chromatin Silencing Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Endoderm Development Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Positive Regulation Of Receptor Biosynthetic Process Histone Deacetylation Hippocampus Development Neuron Differentiation Circadian Regulation Of Gene Expression Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation By Host Of Viral Transcription Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Endopeptidase Activity Negative Regulation Of Androgen Receptor Signaling Pathway Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Amyloid-beta Clearance Regulation Of Signal Transduction By P53 Class Mediator Beta-catenin-TCF Complex Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 p75NTR negatively regulates cell cycle via SC1 Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Deactivation of the beta-catenin transactivating complex ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Repression of WNT target genes Repression of WNT target genes Regulation of TP53 Activity through Acetylation G1/S-Specific Transcription RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Factors involved in megakaryocyte development and platelet production
Drugs			Arsenic trioxide Zinc Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Fingolimod Mocetinostat Abexinostat
Diseases		Gastric cancer Penile cancer Nasopharyngeal cancer Breast cancer Hepatocellular carcinoma Thyroid cancer
GWAS		Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Ulcerative colitis ( 19915572)
Interacting Genes		53 interacting genes: ACTR3 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBIN EZR FER FGFR1 FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MDM2 MYO6 NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 STOML2 UCHL3 VCL YES1	187 interacting genes: APEX1 AR ARID4A ATF3 ATRX BAZ2A BCL11A BCL3 BCL6 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CCN5 CDC20 CDH1 CDKN1A CDYL CHD1 CHD4 CHFR CIITA CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 EZH2 FKBP3 FOXG1 FRA10F GATA3 GCM1 GPS2 H2AC1 H3-4 H3C1 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HNRNPD HR HUS1 IKZF1 ING1 IRF5 JDP2 KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR MAD1L1 MAGEA1 MBD2 MBD3 MBD3L2 MBD4 MDM2 MECOM MECP2 MEN1 MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NR3C1 NRIP1 NUP98 PARP1 PCNA PEX14 PHB PHB2 PHF12 PHF21A PIAS3 PIAS4 PITX2 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RUNX1T1 RUNX3 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SERPINB5 SETDB1 SIN3A SIN3B SMAD2 SMAD3 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUMO2 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TNIP1 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBE2I USP43 VHL ZBTB16 ZMYND11 ZNF76
Entrez ID		999	3065
HPRD ID		01885	03143
Ensembl ID		ENSG00000039068	ENSG00000116478
Uniprot IDs		A0A0U2ZQU7 B3GN61 P12830 Q9UII7	Q13547 Q6IT96
PDB IDs		1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG	1TYI 4BKX 5ICN
Enriched GO Terms of Interacting Partners?
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