PLEKHM1 and GADD45G

Number of citations of the paper that reports this interaction (PubMedID 15383276)
142

Data Source:
BioGRID (two hybrid)

		PLEKHM1	GADD45G
Description		pleckstrin homology and RUN domain containing M1	growth arrest and DNA damage inducible gamma
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GO Annotations	Cellular Component	Nucleolus Lysosomal Membrane Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm
	Molecular Function	Metal Ion Binding	Protein Binding
	Biological Process	Autophagy Protein Transport Lysosome Localization Intracellular Signal Transduction Positive Regulation Of Bone Resorption Positive Regulation Of Ruffle Assembly	Activation Of MAPKKK Activity Apoptotic Process Multicellular Organism Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of P38MAPK Cascade
Pathways
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Cognitive function ( 28093568) Epithelial ovarian cancer ( 25581431) Hip circumference ( 28552196) Male-pattern baldness ( 29146897 28196072) Neuroticism ( 29255261) Parkinson's disease ( 20070850) Remission after SSRI treatment in MDD or neuroticism ( 29559929)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Automobile speeding propensity ( 30643258) Fibrinogen levels ( 28107422 26561523) General cognitive ability ( 29844566) Hand grip strength ( 29691431) Metabolic syndrome ( 31589552) Nonsyndromic cleft lip with cleft palate ( 28232668) Protein quantitative trait loci ( 18464913) Thyroglobulin plasma levels ( 30929638)
Interacting Genes		8 interacting genes: BID EIF2S2 GADD45G MAPK6 MOB4 MUC2 PAFAH1B3 SERPINB9	55 interacting genes: AFAP1L1 APP ARPC5L CCNB1 CDK1 CDKN1A CEP57L1 CRIP2 DDAH2 EEF1A1 EEF1G EIF3G ESR1 EZH2 GADD45B GADD45GIP1 GDF9 HAP1 HP IKBKG KAT5 LRIF1 LUC7L LUC7L2 MAP3K4 MED31 MIDN PCNA PDE4DIP PDIA4 PHAX PIAS4 PLEKHM1 PPARA PPARD PPARG PPIL1 PTN PTPRK RAN RARA RBM48 RDH13 REL RWDD2B RXRA SERPINA4 SGK1 SH3GLB1 SH3GLB2 SMARCB1 TRMT2A TSNAX UTP14A ZNF579
Entrez ID		9842	10912
HPRD ID		11439	05383
Ensembl ID		ENSG00000225190	ENSG00000130222
Uniprot IDs		Q9Y4G2	O95257
PDB IDs		5DPR 5DPS 5DPT 5DPW	2WAL 3FFM
Enriched GO Terms of Interacting Partners?
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