CDK1 and H2AC4

Number of citations of the paper that reports this interaction (PubMedID 22539978)
2

Data Source:
BioGRID (enzymatic study)

		CDK1	H2AC4
Description		cyclin dependent kinase 1	H2A clustered histone 4
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Membrane Centrosome Cytosol Spindle Microtubule Membrane Midbody Extracellular Exosome Mitotic Spindle Cyclin B1-CDK1 Complex	Nucleosome Nuclear Chromatin Nucleus Extracellular Exosome
	Molecular Function	Virus Receptor Activity Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin Binding Hsp70 Protein Binding Histone Kinase Activity Cyclin-dependent Protein Kinase Activity	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Activation Of MAPK Activity Microtubule Cytoskeleton Organization DNA Replication DNA Repair Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Nuclear Envelope Disassembly Mitotic G2 DNA Damage Checkpoint Centrosome Cycle Pronuclear Fusion Cell Aging Cell Proliferation Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Schwann Cell Differentiation Response To Organic Cyclic Compound Response To Amine Response To Activity Cell Migration Histone Phosphorylation Protein Deubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Animal Organ Regeneration Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of DNA Replication Regulation Of Embryonic Development Response To Cadmium Ion Response To Copper Ion Viral Entry Into Host Cell Rhythmic Process Response To Axon Injury Cell Division Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Golgi Disassembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport	Chromatin Organization Chromatin Silencing Negative Regulation Of Cell Proliferation
Pathways		MAPK3 (ERK1) activation E2F-enabled inhibition of pre-replication complex formation Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Golgi Cisternae Pericentriolar Stack Reorganization Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of Cyclin B Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Depolymerisation of the Nuclear Lamina Anchoring of the basal body to the plasma membrane MAPK6/MAPK4 signaling Ovarian tumor domain proteases TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Degradation Mitotic Prophase G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Transcriptional regulation by RUNX2	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation
Drugs		Indirubin-3'-Monoxime Olomoucine Hymenialdisine SU9516 Alvocidib Alsterpaullone AT7519
Diseases
GWAS		Cocaine dependence ( 23958962) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		184 interacting genes: ABL1 AMPH APLP2 AR ARID4A BARD1 BCL2 BIRC5 BIRC6 BRCA1 BRCA2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNE1 CCP110 CD8A CDC20 CDC25A CDC25B CDC25C CDC6 CDCA2 CDCA5 CDK7 CDKN1A CDKN3 CDT1 CEP55 CEP63 CHAF1B CIITA CKS2 CNOT7 CREM CSN2 CSNK2A1 CSNK2B CUX1 CXCR1 DAB2 DCTN6 DNM2 DTL DUT E2F1 ECT2 EEF1D EEF2K EGFR EP300 EPN1 ERCC2 FANCA FANCC FANCG FBXO5 FEN1 FOXM1 FYN GADD45A GADD45B GADD45G GATA2 GBF1 GFAP GOLGA2 GORASP1 H1-0 H1-1 H1-3 H1-5 H2AC4 H2BC3 H4C1 HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 IL16 IL3RA ITGB3 ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LYN LZTS1 MAP4 MAPT MARCKS MBP MCM4 MDM4 MEF2C MKI67 MLKL MNDA MYC MYT1 NCAPD2 NCAPG NCAPH NCL NDE1 NES NPM1 NSFL1C NUP210 PAK6 PBK PCNA PIN1 PITPNM1 PKMYT1 PLEC PML POLA1 PPP2R1A PPP2R1B PPP2R2B PRC1 PTCH1 PTMA PTPN1 PTPN2 PTPN6 PTTG1 RAB4A RAB5B RACGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RGCC RPA2 RPS6KB1 RRM2 RUNX1 RUNX2 SFN SP1 SPAG5 SQSTM1 SSBP1 STK3 STMN1 STMN2 TFDP1 TGFBR2 TK1 TLE1 TNNC1 TOP2A TP53 TP53BP1 TP73 TSC1 TSPYL2 UBA1 UBE2A UBE3A UHRF2 USP16 VIM WEE1 XIAP ZBTB16	23 interacting genes: BAP1 BMI1 BRCA1 CDK1 CDK2 EIF2AK2 EP300 ERCC6 FANCD2 H2BC3 KAT2B KAT5 MAP4K1 MYB PSMD4 PTEN RNF2 RPL6 TRIM37 UBE2D3 UHRF1 USP16 USP51
Entrez ID		983	8335
HPRD ID		00302	09105
Ensembl ID		ENSG00000170312	ENSG00000278463
Uniprot IDs		A0A024QZJ8 B7Z3D6 I6L9I5 P06493	P04908 Q08AJ9
PDB IDs		1LC9 4Y72 4YC3 4YC6 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7	2CV5 2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WKJ 3WTP 3X1S 3X1V 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B40 5CPI 5CPJ 5CPK 5GSE 5GTC 5GXQ 5JRG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACL 6AEE 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94
Enriched GO Terms of Interacting Partners?
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