RAPGEF2 and MT-ATP8

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		RAPGEF2	MT-ATP8
Description		Rap guanine nucleotide exchange factor 2	ATP synthase F0 subunit 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Protein-containing Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm	Mitochondrial Proton-transporting ATP Synthase Complex, Coupling Factor F(o) Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Integral Component Of Membrane
	Molecular Function	Ras Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding WW Domain Binding Phosphatidic Acid Binding	Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	MAPK Cascade Blood Vessel Development Neuron Migration G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Rap Protein Signal Transduction Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration	ATP Biosynthetic Process Cristae Formation Mitochondrial ATP Synthesis Coupled Proton Transport
Pathways		RAF/MAP kinase cascade	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs
Diseases
GWAS		Molybdenum levels ( 26025379) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		12 interacting genes: CTNNB1 HSPA1A KIF5A KIF5B MAGI2 MOB4 MT-ATP8 NEDD4 RALGDS RAP1A RAP2B SPP1	4 interacting genes: GRB2 PACSIN1 RAPGEF2 WNK1
Entrez ID		9693	4509
HPRD ID		19358
Ensembl ID		ENSG00000109756	ENSG00000228253
Uniprot IDs		Q9Y4G8	A0A1X7RCP4 P03928 U5YV54
PDB IDs
Enriched GO Terms of Interacting Partners?
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