CD48 and IL18RAP

Number of citations of the paper that reports this interaction (PubMedID 15760905)
8

Data Source:
HPRD (in vivo)

		CD48	IL18RAP
Description		CD48 molecule	interleukin 18 receptor accessory protein
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GO Annotations	Cellular Component	Plasma Membrane Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Interleukin-18 Receptor Complex
	Molecular Function	Antigen Binding Protein Binding Signaling Receptor Activity	Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Adaptive Immune Response Defense Response Leukocyte Migration	Inflammatory Response Immune Response Cell Proliferation Interferon-gamma Production Interleukin-6 Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Cytokine Production Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide
Pathways		Cell surface interactions at the vascular wall	Interleukin-18 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Blood protein levels ( 30072576 28240269) Celiac disease ( 22057235 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lymphocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Systemic lupus erythematosus ( 28714469)
Interacting Genes		10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK	3 interacting genes: APP CD48 IL18
Entrez ID		962	8807
HPRD ID		00177	05147
Ensembl ID		ENSG00000117091	ENSG00000115607
Uniprot IDs		A0A087X1S7 P09326	O95256
PDB IDs		2EDO	3WO4
Enriched GO Terms of Interacting Partners?
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