RIN1 and ABL2

Number of citations of the paper that reports this interaction (PubMedID 15886098)
53

Data Source:
HPRD (in vivo)

		RIN1	ABL2
Description		Ras and Rab interactor 1	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Dendrite Neuronal Cell Body	Cell Cytosol Actin Cytoskeleton
	Molecular Function	GTPase Activator Activity Protein Binding Ras GTPase Binding	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Endocytosis Signal Transduction Memory Associative Learning Negative Regulation Of Synaptic Plasticity Positive Regulation Of GTPase Activity	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Regulation Of Apoptotic Process Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways		RAB GEFs exchange GTP for GDP on RABs	Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling
Drugs			ATP Dasatinib XL228 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	IgE grass sensitization ( 22036096)
Interacting Genes		19 interacting genes: ABL1 ABL2 AFDN ANKS1B CALCOCO2 EGFR ERBB2 ERBB3 HRAS KRTAP13-1 LZTS2 MTDH RAB5A RAB5B RALGDS RRAS2 YWHAB YWHAE YWHAZ	29 interacting genes: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 MDM2 NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10
Entrez ID		9610	27
HPRD ID		05813	01259
Ensembl ID		ENSG00000174791	ENSG00000143322
Uniprot IDs		A0A0S2Z4U0 Q13671	P42684
PDB IDs			2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?
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