PRDX6 and GPX4

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical, two hybrid)

		PRDX6	GPX4
Description		peroxiredoxin 6	glutathione peroxidase 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Mitochondrion Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nuclear Envelope Nucleoplasm Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Glutathione Peroxidase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Response To Oxidative Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Oxidation-reduction Process Cellular Oxidant Detoxification	Chromatin Organization Phospholipid Metabolic Process Glutathione Metabolic Process Response To Oxidative Stress Multicellular Organism Development Spermatogenesis Aging Lipoxygenase Pathway Response To Estradiol Long-chain Fatty Acid Biosynthetic Process Regulation Of Inflammatory Response Protein Polymerization Oxidation-reduction Process Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs		Isopropyl Alcohol 2-(N-Morpholino)-Ethanesulfonic Acid Copper	Glutathione
Diseases
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)	Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		19 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD RARA SFTPA1 STH SUMO4 TERF1 TERF2IP UCHL5 YWHAE	3 interacting genes: MAPK13 PARK7 PRDX6
Entrez ID		9588	2879
HPRD ID		03817	11819
Ensembl ID		ENSG00000117592	ENSG00000167468
Uniprot IDs		P30041 V9HWC7	P36969 Q6PI42
PDB IDs		1PRX 5B6M 5B6N	2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW
Enriched GO Terms of Interacting Partners?
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