CD40 and MS4A1

Number of citations of the paper that reports this interaction (PubMedID 9933087)
7

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD40	MS4A1
Description		CD40 molecule	membrane spanning 4-domains A1
Image
GO Annotations	Cellular Component	Cell Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Space Cell Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Plasma Membrane Raft Extracellular Exosome
	Molecular Function	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	Epidermal Growth Factor Receptor Binding Protein Binding Immunoglobulin Binding MHC Class II Protein Complex Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Inflammatory Response CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Cobalamin Response To Interferon-gamma Cellular Response To Erythropoietin B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Endothelial Cell Apoptotic Process	Store-operated Calcium Entry Humoral Immune Response Response To Bacterium B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway Protein Tetramerization Calcium Ion Import Into Cytosol
Pathways
Drugs			Rituximab Ibritumomab tiuxetan Tositumomab Ofatumumab Obinutuzumab Ocrelizumab
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 22446961 22446962) Multiple sclerosis ( 22190364 24076602 19525955 21833088) Rheumatoid arthritis ( 30423114 18794853 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)	Recurrent major depressive disorder ( 29317602)
Interacting Genes		26 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG FAF1 HSPA4 HSPA8 IL4R JAK3 MAP3K8 MS4A1 NCOA6 NSMAF PIK3R1 RIPK2 TANK TDP2 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6	10 interacting genes: CD40 CREB3 CSNK2A1 CSNK2A2 FYN KASH5 LCK LMNA LYN MDM2
Entrez ID		958	931
HPRD ID		00178	00204
Ensembl ID		ENSG00000101017	ENSG00000156738
Uniprot IDs		A0A0S2Z349 A0A0S2Z3C7 P25942 Q6P2H9	A0A024R507 P11836
PDB IDs		1CDF 1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9	1S8B 2OSL 3BKY 3PP4
Enriched GO Terms of Interacting Partners?
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