AKAP5 and GABRB3

Number of citations of the paper that reports this interaction (PubMedID 12595241)
50

Data Source:
HPRD (in vivo, in vitro)

		AKAP5	GABRB3
Description		A-kinase anchoring protein 5	gamma-aminobutyric acid type A receptor subunit beta3
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Dendrite Membrane Dendritic Spine Membrane Raft Excitatory Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Cytoplasmic Vesicle Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding	GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity Identical Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Targeting Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Protein Localization To Plasma Membrane	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neuron Apoptotic Process Nervous System Process Roof Of Mouth Development Inhibitory Postsynaptic Potential Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs			Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Olanzapine Clobazam Meprobamate Eszopiclone Alprazolam Zolpidem Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Piperazine Ivermectin Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Ethanol Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Estazolam Sevoflurane Glutethimide Flunitrazepam Bromazepam Clotiazepam Fludiazepam Prazepam Prazepam Quazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Fospropofol Stiripentol Thiocolchicoside Muscimol
Diseases
GWAS			Body mass index ( 28892062) Cognitive performance ( 19734545) Longevity ( 20834067) Pericalcarine cortex volume ( 31530798) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Thyroglobulin plasma levels ( 30929638)
Interacting Genes		14 interacting genes: ADRB2 CALM1 DLG1 DLG4 GABRB1 GABRB3 IQGAP1 KCNJ2 PPP3CA PRKAR2A PRKAR2B PRKCA RET TRPV1	8 interacting genes: AKAP5 ARFGEF2 MEOX2 PPP2CA PRKACA PRKCA RACK1 UBQLN1
Entrez ID		9495	2562
HPRD ID		05255	08844
Ensembl ID		ENSG00000179841	ENSG00000166206
Uniprot IDs		P24588 Q6PG46	B2RCW8 P28472 X5DQY4
PDB IDs		2H9R 3LL8 5NIN	4COF 5O8F 5OJM 6A96 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53
Enriched GO Terms of Interacting Partners?
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