IL27RA and EBI3

Number of citations of the paper that reports this interaction (PubMedID 12121660)
384

Data Source:
HPRD (in vivo, in vitro)

		IL27RA	EBI3
Description		interleukin 27 receptor subunit alpha	Epstein-Barr virus induced 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Cytokine Binding Interleukin-27 Receptor Activity	Cytokine Receptor Activity Cytokine Activity Protein Binding Cytokine Binding Interleukin-27 Receptor Binding
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Tumor Necrosis Factor Secretion Negative Regulation Of Interleukin-17 Secretion Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Humoral Immune Response T-helper 1 Type Immune Response T Cell Proliferation Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Proliferation Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Interleukin-35 Signalling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		5 interacting genes: EBI3 GDF15 IL27 MAPK8 STAT1	6 interacting genes: CANX GOSR1 IL12A IL27RA MDFI SMAD3
Entrez ID		9466	10148
HPRD ID		09247	12051
Ensembl ID		ENSG00000104998	ENSG00000105246
Uniprot IDs		Q6UWB1	Q14213
PDB IDs
Enriched GO Terms of Interacting Partners?
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