PICK1 and ASIC1

Number of citations of the paper that reports this interaction (PubMedID 11739374)
51

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PICK1	ASIC1
Description		protein interacting with PRKCA 1	acid sensing ion channel subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Aggresome Cell Junction Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Postsynaptic Early Endosome	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Synapse
	Molecular Function	G Protein-coupled Receptor Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity	Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity Acid-sensing Ion Channel Activity
	Biological Process	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance	Behavioral Fear Response Response To Amphetamine Sodium Ion Transport Signal Transduction Memory Associative Learning Response To PH Response To Acidic PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neurotransmitter Secretion Sensory Perception Of Sour Taste Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To PH
Pathways		Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors	Stimuli-sensing channels
Drugs			Diclofenac Amiloride
Diseases
GWAS		Body fat percentage ( 26833246)
Interacting Genes		47 interacting genes: AFDN AKT1 APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBIN F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 JAM3 LRP2BP NECTIN2 NECTIN4 PRKCA PRKCG PRKN PRLHR SACS SLC6A3 UBQLN4 USP7	5 interacting genes: ASIC2 ATXN3 PICK1 PRKACA STOM
Entrez ID		9463	41
HPRD ID		16176	04182
Ensembl ID		ENSG00000100151	ENSG00000110881
Uniprot IDs		A0A024R1J5 Q9NRD5	A8K1U5 P78348
PDB IDs		2GZV 6AR4 6BJN 6BJO
Enriched GO Terms of Interacting Partners?
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