HOMER1 and GRIK1

Number of citations of the paper that reports this interaction (PubMedID 9069287)
283

Data Source:
HPRD (in vitro, in vivo)

		HOMER1	GRIK1
Description		homer scaffold protein 1	glutamate ionotropic receptor kainate type subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Z Disc Cell Junction Axon Dendrite Neuron Projection Costamere Dendritic Spine Neuron Spine Apical Part Of Cell Glutamatergic Synapse Postsynaptic Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Postsynaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Protein Binding G Protein-coupled Glutamate Receptor Binding Signaling Adaptor Activity Ion Channel Binding	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Skeletal Muscle Contraction Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Protein Tetramerization Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Calcium Ion Import Regulation Of Postsynaptic Neurotransmitter Receptor Activity Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity	Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Central Nervous System Development Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic Acid Topiramate
Diseases
GWAS		Bipolar disorder ( 31043756) Blood and toenail selenium levels ( 25343990) Height ( 18193045) Hepcidin/ferritin ratio ( 27846281) Lateral ventricle temporal horn volume ( 31530798) Major depressive disorder ( 20673876) Metabolite levels ( 23823483) Toenail selenium levels ( 25343990)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Forehead morphology ( 29921221) Generalized epilepsy ( 30531953) Glucocorticoid-induced osteonecrosis ( 26265699) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Periodontitis (DPAL) ( 24024966) Plasma parathyroid hormone levels ( 30134803) Response to statin therapy ( 20339536) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		20 interacting genes: ABI3 AGAP2 C19orf57 C1orf116 DBNL DNM3 EFNB2 FAT1 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 RYR1 RYR2 SHANK1 STX12 TANC1 TRPC1	6 interacting genes: DLG4 FLNA GRIP1 HOMER1 PICK1 SDCBP
Entrez ID		9456	2897
HPRD ID		09211	00693
Ensembl ID		ENSG00000152413	ENSG00000171189
Uniprot IDs		Q5U5K4 Q86YM7	B7Z256 B7Z3V7 E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086
PDB IDs			2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
Enriched GO Terms of Interacting Partners?
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