CD28 and CD86

Number of citations of the paper that reports this interaction (PubMedID 11021528)
21

Data Source:
HPRD (in vivo)

		CD28	CD86
Description		CD28 molecule	CD86 molecule
Image
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Protein Complex Involved In Cell Adhesion	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protease Binding SH3/SH2 Adaptor Activity Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Immune System Process Positive Regulation Of Inflammatory Response To Antigenic Stimulus Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation T Cell Activation Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Defense Response To Virus By Virus T Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway	Adaptive Immune Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide
Pathways		PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept
Diseases
GWAS		Alopecia areata ( 25608926) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Graves' disease ( 21841780) Heschl's gyrus morphology ( 25130324) Inflammatory bowel disease ( 26192919) Multiple sclerosis ( 31604244 24076602) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 23603763 27992413) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 26192919)	Diffuse large B cell lymphoma ( 25261932) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		18 interacting genes: BCS1L CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC	6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		940	942
HPRD ID		01727	03011
Ensembl ID		ENSG00000178562	ENSG00000114013
Uniprot IDs		B4E0L1 P10747	A0A0X9R4E0 A8K632 P42081
PDB IDs		1YJD 3WA4 5AUL 5GJH 5GJI 6O8D	1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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