ADIPOQ and ADIPOR2

Number of citations of the paper that reports this interaction (PubMedID 12802337)
624

Data Source:
HPRD (in vivo)

		ADIPOQ	ADIPOR2
Description		adiponectin, C1Q and collagen domain containing	adiponectin receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Cell Surface Collagen-containing Extracellular Matrix	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Extracellular Matrix Structural Constituent Protein Binding Sialic Acid Binding Identical Protein Binding Protein Homodimerization Activity	Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Adiponectin Binding Adipokinetic Hormone Receptor Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Beta-oxidation Signal Transduction Response To Nutrient Circadian Rhythm Response To Bacterium Response To Sucrose Response To Glucose Positive Regulation Of Signal Transduction Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Response To Activity Fatty Acid Oxidation Negative Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Low-density Lipoprotein Particle Clearance Response To Tumor Necrosis Factor Cellular Response To Drug Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Response To Ethanol Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Phagocytosis Negative Regulation Of Synaptic Transmission Brown Fat Cell Differentiation Protein Homooligomerization Response To Glucocorticoid Negative Regulation Of ERK1 And ERK2 Cascade Response To Linoleic Acid Detection Of Oxidative Stress Cellular Response To CAMP Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Response To Epinephrine Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Intracellular Protein Transport Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Receptor Binding Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Renal Albumin Absorption Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Metanephric Mesenchymal Cell Migration	Heart Development Female Pregnancy Response To Nutrient Hormone-mediated Signaling Pathway Fatty Acid Oxidation Negative Regulation Of Cell Growth Adiponectin-activated Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Positive Regulation Of Glucose Import Vascular Wound Healing Positive Regulation Of Cold-induced Thermogenesis
Pathways		AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation	AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity
Drugs
Diseases		Adiponectin deficiency
GWAS		Activated partial thromboplastin time ( 22703881) Adiponectin levels ( 21700879 26299439 20876611 20011104 22479202 20018283 19165155 24105470) Adiponectin levels (BMI-adjusted) ( 26299439) Adiponectin levels in pregnancy ( 28317342) Blood protein levels ( 30072576) Copper levels ( 26025379)	Adverse response to lamotrigine and phenytoin ( 22379998) Urate levels in lean individuals ( 25811787)
Interacting Genes		6 interacting genes: ADIPOR2 BNIP3L CDH13 KASH5 SGTA SYNE4	2 interacting genes: ADIPOQ APPL1
Entrez ID		9370	79602
HPRD ID		05671	06403
Ensembl ID		ENSG00000181092	ENSG00000006831
Uniprot IDs		A8K660 B2R773 Q15848	Q86V24
PDB IDs		4DOU	3WXW 5LWY 5LX9 5LXA
Enriched GO Terms of Interacting Partners?
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