CADPS2 and BDNF

Number of citations of the paper that reports this interaction (PubMedID 14715936)
35

Data Source:
HPRD (in vivo, in vitro)

		CADPS2	BDNF
Description		calcium dependent secretion activator 2	brain derived neurotrophic factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cell Junction Cytoplasmic Vesicle Membrane Presynaptic Membrane Intracellular Membrane-bounded Organelle Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse	Extracellular Region Extracellular Space Cytoplasm Mitochondrion Synaptic Vesicle Nuclear Speck Secretory Granule Axon Dendrite Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Postsynapse
	Molecular Function	Lipid Binding Metal Ion Binding	Protein Binding Growth Factor Activity
	Biological Process	Exocytosis Cellular Response To Starvation Protein Transport Synaptic Vesicle Priming Positive Regulation Of Exocytosis Dense Core Granule Exocytosis	Ureteric Bud Development Behavioral Fear Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Gamma-aminobutyric Acid Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Axon Guidance Axon Target Recognition Synapse Assembly Peripheral Nervous System Development Memory Circadian Rhythm Feeding Behavior Neuron Recognition Negative Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Glutamate Secretion Dendrite Development Nerve Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Regulation Of Retinal Cell Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Collateral Sprouting Positive Regulation Of Collateral Sprouting Axon Extension Neuron Projection Morphogenesis Inner Ear Development Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Inhibitory Postsynaptic Potential Taste Bud Development Dendrite Extension Retrograde Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission Positive Regulation Of Receptor Binding Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Protein Localization To Cell Surface Negative Regulation Of Apoptotic Signaling Pathway
Pathways			MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5
Drugs		Calcium Citrate Calcium Phosphate	CX717 Copper Chondroitin sulfate
Diseases			Congenital central hypoventilation syndrome (CCHS)
GWAS		Attention deficit hyperactivity disorder ( 30478444) Brain structure ( 20171287) General risk tolerance (MTAG) ( 30643258) Menarche (age at onset) ( 25231870) Number of sexual partners ( 30643258) Serum sulfate level ( 27412988) Smoking status (ever vs never smokers) ( 30643258) Waist circumference ( 28552196)	Alcohol consumption ( 31358974) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 23563607 19079260 26961502 24861553 31453325 28892062 25673413 20935630 29273807 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Childhood body mass index ( 26604143) Chloride levels ( 29403010) Chronotype ( 30696823) Coffee consumption (cups per day) ( 25288136) Coronary artery disease ( 29212778) Diastolic blood pressure ( 28135244 27841878) Diverticular disease ( 30177863) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965) Metabolic syndrome ( 31589552) Morning person ( 30696823) Obesity ( 21708048 23563607) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking behavior ( 20418890) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Urinary sodium excretion ( 31409800) Waist circumference ( 25673412) Weight ( 28552196 19079260)
Interacting Genes		15 interacting genes: BDNF DMD DRD2 MEGF10 SRPK2 TSPOAP1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U UBE2W	16 interacting genes: AGO3 APP CADPS2 CPE ESR1 F11R INPP5K JUNB MBTPS1 NCAM1 NOS3 NTF3 NTF4 NTRK2 RHOU SORT1
Entrez ID		93664	627
HPRD ID		12996	00214
Ensembl ID		ENSG00000081803	ENSG00000176697
Uniprot IDs		B7ZM57 Q86UW7 X5DNG0	A0A0E3SU01 P23560
PDB IDs			1B8M 1BND
Enriched GO Terms of Interacting Partners?
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