LHX2 and RLIM

Number of citations of the paper that reports this interaction (PubMedID 10431247)
47

Data Source:
HPRD (in vitro)

		LHX2	RLIM
Description		LIM homeobox 2	ring finger protein, LIM domain interacting
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleus Nucleoplasm Cytosol Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Transcription Factor Binding Metal Ion Binding	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Neural Tube Closure Hair Follicle Development Axon Guidance Mesoderm Development Dorsal/ventral Pattern Formation Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome Regulation Of Dosage Compensation By Inactivation Of X Chromosome
Pathways		Regulation of expression of SLITs and ROBOs	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		6 interacting genes: CITED2 DNMT3L LDB1 MSX1 PAX6 RLIM	30 interacting genes: BRF1 ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LNX2 MDM2 PDLIM1 REXO1 RPS14 SIN3A SMAD7 SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2K
Entrez ID		9355	51132
HPRD ID		04786	02304
Ensembl ID		ENSG00000106689	ENSG00000131263
Uniprot IDs		B3KNJ5 P50458	Q9NVW2
PDB IDs
Enriched GO Terms of Interacting Partners?
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