TRIP10 and WAS

Number of citations of the paper that reports this interaction (PubMedID 10713100)
41

Data Source:
HPRD (two hybrid, in vitro)

		TRIP10	WAS
Description		thyroid hormone receptor interactor 10	WASP actin nucleation promoting factor
Image
GO Annotations	Cellular Component	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Cell Cortex Cell Projection Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Cytosol Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Actin Cortical Patch Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding Rac GTPase Binding Actin Filament Binding
	Biological Process	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Membrane Organization	Actin Cortical Patch Assembly Regulation Of T Cell Antigen Processing And Presentation Endocytosis Defense Response Immune Response Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Regulation Of Cell Shape Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Actin Nucleation Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Actin Cortical Patch Localization Protein-containing Complex Assembly Cellular Response To Interferon-gamma Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Rho GTPase cycle Clathrin-mediated endocytosis	Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			(S)-Wiskostatin
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS
Interacting Genes		28 interacting genes: ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 HTT LYN PDE6G POT1 PRKACA RHOJ RHOQ RXRA SH3BP1 SMARCE1 SMURF1 SRC STAT3 TERF1 THRB TINF2 WAS WASF1 WASL WBP11	55 interacting genes: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2
Entrez ID		9322	7454
HPRD ID		05142	02314
Ensembl ID		ENSG00000125733	ENSG00000015285
Uniprot IDs		Q15642 W4VSQ9	A0A024QYX8 P42768
PDB IDs		2CT4 2EFK 2KE4	1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?
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