DLGAP1 and GRIN2C

Number of citations of the paper that reports this interaction (PubMedID 9694864)
78

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DLGAP1	GRIN2C
Description		DLG associated protein 1	glutamate ionotropic receptor NMDA type subunit 2C
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Plasma Membrane Postsynaptic Density Cell Junction	Cell Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Cell Junction Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Protein-containing Complex Binding	NMDA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Chemical Synaptic Transmission	Glutamate Receptor Signaling Pathway Brain Development Response To Wounding Calcium-mediated Signaling Directional Locomotion Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic Acid Glycine Atomoxetine Pentobarbital Secobarbital Pethidine Acamprosate Gabapentin Phenobarbital Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases
GWAS		Alanine aminotransferase levels ( 31219225) Body fat mass ( 28552196) Cardiac Troponin-T levels ( 23247143) Eating disorders ( 22911880) Economic and political preferences (time) ( 22566634) Erythrocyte cadmium concentration in never smokers ( 27005419) Hip circumference adjusted for BMI ( 28552196) Initial alcohol sensitivity ( 30276832) Menarche (age at onset) ( 27182965 25231870) Midgestational circulating levels of PBDEs ( 28235828) Obesity-related traits ( 23251661) Plasma free amino acid levels ( 30659259) Response to fenofibrate (total cholesterol levels) ( 27002377) Trunk fat mass ( 28552196) Upper eyelid sagging severity ( 24869959)	Congenital heart disease (maternal effect) ( 28468790)
Interacting Genes		21 interacting genes: APC DLG1 DLG2 DLG3 DLG4 DLGAP2 DLGAP3 DYNLL1 DYNLL2 GRB2 GRIN2A GRIN2C ITSN1 ITSN2 KCNA4 MYO5A SHANK1 SHANK2 SHANK3 SORBS2 TANC1	6 interacting genes: DLG3 DLG4 DLGAP1 ERBIN IL16 PATJ
Entrez ID		9229	2905
HPRD ID		09260	00699
Ensembl ID		ENSG00000170579	ENSG00000161509
Uniprot IDs		A0A0A0MTP4 A8MXQ8 B7Z2J5 O14490 Q6IS01	H0Y2V8 O15398 Q14957 Q8IW23
PDB IDs		5YPO
Enriched GO Terms of Interacting Partners?
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