LRRFIP1 and MED4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LRRFIP1	MED4
Description		LRR binding FLII interacting protein 1	mediator complex subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity Cadherin Binding	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type I Interferon Production Negative Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Pathways		Signaling by cytosolic FGFR1 fusion mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 in disease	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Adiposity ( 23505185) Longevity ( 30294719)	Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		6 interacting genes: CEP44 FBXO7 FLII MED4 SERPINB5 SH2D2A	33 interacting genes: AMOT AP2M1 ATF7IP C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TXLNA USHBP1 WDTC1
Entrez ID		9208	29079
HPRD ID		04460	16145
Ensembl ID		ENSG00000124831	ENSG00000136146
Uniprot IDs		A0A0F7NGI8 B4DPC0 Q32MZ4	A0A024RDY7 Q9NPJ6
PDB IDs		4H22
Enriched GO Terms of Interacting Partners?
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