ACY3 and PMM2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		ACY3	PMM2
Description		aminoacylase 3	phosphomannomutase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Extracellular Exosome	Nucleoplasm Cytosol Neuronal Cell Body
	Molecular Function	Molecular_function Aminoacylase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding	Phosphomannomutase Activity Protein Binding
	Biological Process	Xenobiotic Metabolic Process Biological_process Viral Process	Mannose Metabolic Process Protein Glycosylation Protein N-linked Glycosylation GDP-mannose Biosynthetic Process Protein Targeting To ER
Pathways		Aflatoxin activation and detoxification	Defective PMM2 causes PMM2-CDG (CDG-1a) Synthesis of GDP-mannose
Drugs		L-Aspartic Acid
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Serum metabolite levels ( 24625756) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Glaucoma (high intraocular pressure) ( 25173107)
Interacting Genes		14 interacting genes: AAMDC ASPA GORASP2 KRTAP10-3 KRTAP10-8 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 RARG RRAS	2 interacting genes: ACY3 ZC3H7A
Entrez ID		91703	5373
HPRD ID		12422	03472
Ensembl ID		ENSG00000132744	ENSG00000140650
Uniprot IDs		A0A024R5L2 Q96HD9	A0A0S2Z4J6 O15305 Q59F02
PDB IDs			2AMY 2Q4R
Enriched GO Terms of Interacting Partners?
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