EXO1 and PMS2

Number of citations of the paper that reports this interaction (PubMedID 11427529)
53

Data Source:
HPRD (in vivo, in vitro)

		EXO1	PMS2
Description		exonuclease 1	PMS1 homolog 2, mismatch repair system component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body	Nucleus Nucleoplasm Cytosol Plasma Membrane Mismatch Repair Complex MutLalpha Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	DNA Binding Chromatin Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity 5'-3' Exodeoxyribonuclease Activity Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity	DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding ATPase Activity Single Base Insertion Or Deletion Binding MutSalpha Complex Binding
	Biological Process	Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Replication DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle RNA Phosphodiester Bond Hydrolysis, Endonucleolytic T-circle Formation Regulation Of Signal Transduction By P53 Class Mediator	Mismatch Repair Somatic Hypermutation Of Immunoglobulin Genes Response To Drug Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs			Adenosine 5'-[Î³-thio]triphosphate
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Keratinocyte cancer (MTAG) ( 31174203) Menopause (age at onset) ( 22267201 26414677)
Interacting Genes		18 interacting genes: ATM DCAF1 KPNA4 KPNB1 MLH1 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	4 interacting genes: EXO1 MLH1 PCNA UBC
Entrez ID		9156	5395
HPRD ID		06932	02598
Ensembl ID		ENSG00000174371	ENSG00000122512
Uniprot IDs		A8K5H6 Q9UQ84	A0A2R8Y6S3 B4DGM0 C9J167 P54278 Q7Z3Q2
PDB IDs		3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E	1EA6 1H7S 1H7U 5U5R 6MFQ
Enriched GO Terms of Interacting Partners?
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