CREB3L1 and GPR25

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CREB3L1	GPR25
Description		cAMP responsive element binding protein 3 like 1	G protein-coupled receptor 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding SMAD Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Multicellular Organism Development Negative Regulation Of Gene Expression Viral Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	G Protein-coupled Receptor Signaling Pathway
Pathways		CREB3 factors activate genes	G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Systolic blood pressure ( 30578418)	Ankylosing spondylitis ( 23749187)
Interacting Genes		30 interacting genes: C5 CD99L2 CFHR5 CREB3 CREB3L3 CREM CYBC1 DDIT3 FAM3C FXYD3 FXYD6 GPR25 HIF1A JAGN1 MFSD5 NRM PGAP2 PGRMC1 PLN PLP1 PRKAB2 RUNX1T1 SLC30A8 SLC35B4 TMEM11 TMEM128 TMEM147 TMEM218 TMEM234 TSPO	9 interacting genes: CREB3L1 FATE1 GGT7 KASH5 LMNA MAP3K7 NAALADL2 PNMA1 VAPB
Entrez ID		90993	2848
HPRD ID		16751	03707
Ensembl ID		ENSG00000157613	ENSG00000170128
Uniprot IDs		B2RA75 Q96BA8	O00155
PDB IDs
Enriched GO Terms of Interacting Partners?
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