GADD45GIP1 and EXOSC4

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GADD45GIP1	EXOSC4
Description		GADD45G interacting protein 1	exosome component 4
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Ribosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Viral Process Mitochondrial Translational Elongation Mitochondrial Translational Termination Mitotic Cell Cycle Arrest	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		11 interacting genes: APP AR CSNK2B EXOSC4 FBXO7 GADD45A GADD45B GADD45G IKBKG NR4A1 UPF2	28 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LRRC8D MPP6 MPZL1 MTREX NEK1 SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		90480	54512
HPRD ID		05519	16221
Ensembl ID		ENSG00000179271	ENSG00000178896
Uniprot IDs		Q8TAE8	Q9NPD3
PDB IDs		3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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