MTMR2 and SBF1

Number of citations of the paper that reports this interaction (PubMedID 12668758)
46

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		MTMR2	SBF1
Description		myotubularin related protein 2	SET binding factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Vacuolar Membrane Cytosol Synaptic Vesicle Postsynaptic Density Axon Dendrite Early Endosome Membrane Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Synaptic Membrane	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Nuclear Body Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Identical Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Rab Guanyl-nucleotide Exchange Factor Activity Phosphatase Regulator Activity
	Biological Process	Negative Regulation Of Receptor Internalization Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Endocytosis Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Neuron Development Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Spermatogenesis Regulation Of GTPase Activity
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane	Synthesis of PIPs at the ER membrane RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		6 interacting genes: ERBB3 ERBB4 NEFL ROR2 SBF1 SNTA1	8 interacting genes: AATK CYB5R3 HSPB1 KMT2A MTMR2 PDPK1 SUV39H1 TNFSF11
Entrez ID		8898	6305
HPRD ID		04650	06788
Ensembl ID		ENSG00000087053	ENSG00000100241
Uniprot IDs		A0A024R3B7 Q13614	O95248
PDB IDs		1LW3 1M7R 1ZSQ 1ZVR 5GNH
Enriched GO Terms of Interacting Partners?
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