EIF2B2 and C9orf72

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		EIF2B2	C9orf72
Description		eukaryotic translation initiation factor 2B subunit beta	C9orf72-SMCR8 complex subunit
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	P-body Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytoplasmic Stress Granule Dendrite Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Perikaryon Axonal Growth Cone Main Axon Atg1/ULK1 Kinase Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding	Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Ovarian Follicle Development Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone T Cell Receptor Signaling Pathway	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Stress Granule Assembly Axon Extension Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Negative Regulation Of GTP Binding Regulation Of Autophagosome Assembly
Pathways		Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Mood instability ( 29187730)	Amyotrophic lateral sclerosis ( 30976013 25442119 29566793 22959728 27455348 19734901 20801718 24931836) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)
Interacting Genes		12 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 NPC2 PCGF6	7 interacting genes: APP CRX EIF2B2 NMI REL SMN1 SRPK1
Entrez ID		8892	203228
HPRD ID		05923	12975
Ensembl ID		ENSG00000119718	ENSG00000147894
Uniprot IDs		P49770 Q53XC2	Q96LT7
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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