TNFRSF10B and CFLAR

Number of citations of the paper that reports this interaction (PubMedID 9325248)
100

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		TNFRSF10B	CFLAR
Description		TNF receptor superfamily member 10b	CASP8 and FADD like apoptosis regulator
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Ripoptosome
	Molecular Function	Protein Binding Signaling Receptor Activity TRAIL Binding	Protease Binding Death Receptor Binding Protein Binding Enzyme Activator Activity Peptidase Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Leukocyte Migration Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Development Response To Bacterium Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Viral Process Cellular Response To Insulin Stimulus Response To Testosterone Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Apoptotic Signaling Pathway Negative Regulation Of Myoblast Fusion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling	TRAIL signaling
Drugs		HGS-TR2J
Diseases
GWAS		Blood protein levels ( 30072576) Renal cell carcinoma ( 28598434)	Rheumatoid arthritis ( 30423114 24390342) Triptolide cytotoxicity ( 26121980)
Interacting Genes		10 interacting genes: CASP8 CFLAR FADD MADD RIPK1 TIMM50 TNFRSF10A TNFRSF10D TNFSF10 TRADD	25 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 NFKB1 PSEN2 RAF1 RIPK1 RIPK2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 USP8
Entrez ID		8795	8837
HPRD ID		04680	04671
Ensembl ID		ENSG00000120889	ENSG00000003402
Uniprot IDs		O14763 Q7Z2I8	A0A024R3Y3 A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61
PDB IDs		1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY	2N5R 3H11 3H13
Enriched GO Terms of Interacting Partners?
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