PABPC4 and RIF1

Number of citations of the paper that reports this interaction (PubMedID 15383276)
142

Data Source:
HPRD (two hybrid)

		PABPC4	RIF1
Description		poly(A) binding protein cytoplasmic 4	replication timing regulatory factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Chromosome, Telomeric Region Nuclear Chromatin Condensed Chromosome Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Body Nuclear Membrane Site Of Double-strand Break Spindle Midzone
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	Protein Binding
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Nonhomologous End Joining Chromatin Silencing At Telomere Cellular Response To DNA Damage Stimulus Cell Cycle Stem Cell Population Maintenance Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of Histone H3-K9 Methylation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Nonhomologous End-Joining (NHEJ)
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Diastolic blood pressure ( 27618448) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 27863252) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Lung cancer ( 23143601) Metabolite levels ( 23823483)
Interacting Genes		23 interacting genes: EEF1A1 FOXD3 GDF9 HAP1 HCRTR1 IL7R LUC7L2 MED31 MKNK1 MTF1 NMNAT1 PHLDA1 PRKCG RIF1 S100A8 SETDB1 SMAD9 SREK1 SRPK2 UBC VPS26B XRN1 ZNF655	19 interacting genes: BRD7 CEP126 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 LINC00839 NSG2 PABPC4 PIAS4 POT1 PPP1CA PPP1CC SETDB1 SMARCD1 TERF2IP
Entrez ID		8761	55183
HPRD ID		04557	10603
Ensembl ID		ENSG00000090621	ENSG00000080345
Uniprot IDs		Q13310	Q5UIP0
PDB IDs
Enriched GO Terms of Interacting Partners?
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