ADAM19 and TNFSF11

Number of citations of the paper that reports this interaction (PubMedID 12682046)
17

Data Source:
HPRD (in vitro)

		ADAM19	TNFSF11
Description		ADAM metallopeptidase domain 19	TNF superfamily member 11
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding SH3 Domain Binding Metal Ion Binding	Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding
	Biological Process	Placenta Development Membrane Protein Ectodomain Proteolysis Positive Regulation Of Gene Expression Extracellular Matrix Organization Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Ossification Osteoclast Proliferation Monocyte Chemotaxis Immune Response Activation Of JUN Kinase Activity Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Osteoclast Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Osteoclast Development Paracrine Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Tooth Eruption Bone Resorption Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Protein Kinase B Signaling Calcium Ion Homeostasis Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Actin Binding Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Osteoclast Development
Pathways		Invadopodia formation	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			Lenalidomide Denosumab Thiocolchicoside
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Blood protein levels ( 30072576) Body mass index ( 28552196) Chronic obstructive pulmonary disease ( 28166215 30804561) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (adrenergics, inhalants) ( 31015401) Peak expiratory flow ( 30804560) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Triglyceride levels ( 31647587)	Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740 23437003) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) C-reactive protein levels ( 24763700) Cortical thickness ( 22792071) Crohn's disease ( 21102463) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Serum alkaline phosphatase levels ( 29403010) Vitiligo ( 27723757)
Interacting Genes		7 interacting genes: A2M ABI2 COPB1 FURIN NRG1 SH3GL2 TNFSF11	30 interacting genes: ADAM17 ADAM19 AKT1 BBS10 CEP126 DDAH2 EEF1A1 EZH2 LMO4 MAPK1 MAPK3 MAPK8 MBTPS1 MED24 MMP1 MMP3 MMP7 NFKB1 NFKBIA PHAX PLK1 PRXL2B SBF1 SNRNP35 TMOD3 TNFRSF11A TNFRSF11B TRAF6 TRMT2A ZC3HC1
Entrez ID		8728	8600
HPRD ID		04704	04031
Ensembl ID		ENSG00000135074	ENSG00000120659
Uniprot IDs		Q8TBU7 Q9H013	O14788 Q54A98 Q5T9Y4
PDB IDs			3URF 5BNQ
Enriched GO Terms of Interacting Partners?
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