EIF3H and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EIF3H	SORBS3
Description		eukaryotic translation initiation factor 3 subunit H	sorbin and SH3 domain containing 3
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Polysomal Ribosome Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Metallopeptidase Activity	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Proteolysis	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Asthma ( 29273806) Body mass index ( 25673413) Colorectal cancer ( 26965516 25990418 18372905 30529582 21761138 26151821 29471430 24737748) Colorectal cancer or advanced adenoma ( 30510241) Corneal curvature ( 22969067) Height ( 31562340) Metabolite levels ( 23823483) Morning person ( 30696823) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Right lateral prefrontal cortical growth ( 29682794) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference adjusted for body mass index ( 28552196)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		9 interacting genes: ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS3 SPTBN1	46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		8667	10174
HPRD ID		04885	11535
Ensembl ID		ENSG00000147677	ENSG00000120896
Uniprot IDs		O15372 Q6IB98	O60504
PDB IDs		3J8B 3J8C	2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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