EIF3A and PAIP1

Number of citations of the paper that reports this interaction (PubMedID 24396066)
12

Data Source:
BioGRID (pull down)

		EIF3A	PAIP1
Description		eukaryotic translation initiation factor 3 subunit A	poly(A) binding protein interacting protein 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytoplasm Cytosol
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding	RNA Binding Protein Binding Translation Activator Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translation Reinitiation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation MRNA Stabilization
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Deadenylation of mRNA
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)	Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		20 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 MTNR1B PAIP1 REL RNF139 SRPK2 TFIP11 UBC UPF1 YWHAZ	6 interacting genes: EIF3A EIF3B EIF4A1 PABPC1 UBR5 WWP2
Entrez ID		8661	10605
HPRD ID		03618	05539
Ensembl ID		ENSG00000107581	ENSG00000172239
Uniprot IDs		Q14152	Q9H074
PDB IDs		3J8B 3J8C	1JH4 3NTW 3RK6
Enriched GO Terms of Interacting Partners?
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