TNKS and TNKS1BP1

Number of citations of the paper that reports this interaction (PubMedID 12080061)
52

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		TNKS	TNKS1BP1
Description		tankyrase	tankyrase 1 binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nuclear Pore Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Membrane Mitotic Spindle Pole	Nucleus Nuclear Heterochromatin Cytoplasm Cytosol Cytoskeleton Adherens Junction CCR4-NOT Complex
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein ADP-ribosylase Activity	Protein Binding Enzyme Binding Protein-containing Complex Binding Cadherin Binding Ankyrin Repeat Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cellular Response To Nutrient Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Positive Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric DNA Binding Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric	Nuclear-transcribed MRNA Poly(A) Tail Shortening Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Telomere Maintenance Via Telomerase Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Ionizing Radiation
Pathways		TCF dependent signaling in response to WNT Degradation of AXIN XAV939 inhibits tankyrase, stabilizing AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Bone mineral density (Ward's triangle area) ( 27397699) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Schizophrenia ( 26198764) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 2 diabetes ( 30054458)	Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: AXIN1 BABAM1 DISC1 EIF4A1 FANCD2 FNBP1 LNPEP MCL1 NELFE NUMA1 POT1 PTEN SH3BP5 TERF1 TNIK TNKS1BP1 TNKS2 USP25 VPS33A	3 interacting genes: CSNK2A1 TNKS TNKS2
Entrez ID		8658	85456
HPRD ID		04490	06164
Ensembl ID		ENSG00000173273	ENSG00000149115
Uniprot IDs		O95271	A0A024R542 Q9C0C2
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU
Enriched GO Terms of Interacting Partners?
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