PRKRA and SNX5

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PRKRA	SNX5
Description		protein activator of interferon induced protein kinase EIF2AK2	sorting nexin 5
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex	Ruffle Phagocytic Cup Endosome Cytosol Brush Border Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Protein Heterodimerization Activity Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Protein Phosphorylation Immune Response Negative Regulation Of Cell Proliferation Response To Virus MiRNA Metabolic Process Viral Process Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Catalytic Activity Skeletal System Morphogenesis Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Intracellular Protein Transport Pinocytosis Epidermal Growth Factor Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Renal Sodium Excretion Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)	Cholesterol, total ( 25961943) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		21 interacting genes: AGO2 CEBPZ CEP126 COPS6 DICER1 EIF2AK2 GDF9 LYAR NKRF POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746	15 interacting genes: APPBP2 AQP2 CDC37 CLTC CLTCL1 DNAJB11 FANCA HGS HMOX2 ITSN1 MESD MIB1 PFDN1 PRKRA SNX2
Entrez ID		8575	27131
HPRD ID		04573	10439
Ensembl ID		ENSG00000180228	ENSG00000089006
Uniprot IDs		B4DJC7 O75569	Q6P5V6 Q9Y5X3
PDB IDs		2DIX	1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z
Enriched GO Terms of Interacting Partners?
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