PIAS1 and MDM2

Number of citations of the paper that reports this interaction (PubMedID 12393906)
31

Data Source:
HPRD (in vitro)

		PIAS1	MDM2
Description		protein inhibitor of activated STAT 1	MDM2 proto-oncogene
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Body Endocytic Vesicle Membrane Protein-containing Complex Synapse
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding 5S RRNA Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Receptor Serine/threonine Kinase Binding Identical Protein Binding Peroxisome Proliferator Activated Receptor Binding Ribonucleoprotein Complex Binding Ubiquitin Binding Protein N-terminus Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Scaffold Protein Binding Disordered Domain Specific Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II JAK-STAT Cascade Spermatogenesis Visual Learning Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway Protein-DNA Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Blood Vessel Development Blood Vessel Remodeling Regulation Of Heart Rate Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development Ubiquitin-dependent Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Traversing Start Control Point Of Mitotic Cell Cycle Positive Regulation Of Cell Proliferation Response To Iron Ion Positive Regulation Of Gene Expression Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Viral Process Protein Ubiquitination Protein Deubiquitination Protein Sumoylation Peptidyl-lysine Modification Protein Destabilization Response To Magnesium Ion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Transcription Factor Catabolic Process Regulation Of Protein Catabolic Process Response To Cocaine Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Morphine Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Establishment Of Protein Localization Response To Ether Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Response To Antibiotic Positive Regulation Of Protein Export From Nucleus Response To Steroid Hormone Positive Regulation Of Muscle Cell Differentiation Proteolysis Involved In Cellular Protein Catabolic Process Protein Autoubiquitination Cardiac Septum Morphogenesis Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Negative Regulation Of Cell Cycle Arrest Cellular Response To Vitamin B1 Cellular Response To Alkaloid Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To UV-C Cellular Response To Actinomycin D Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Formaldehyde Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Amyloid Fibril Formation Response To Water-immersion Restraint Stress
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling	AKT phosphorylates targets in the cytosol Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins Trafficking of AMPA receptors Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53 Regulation of RUNX3 expression and activity
Drugs			Zinc Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Diseases			Choriocarcinoma Osteosarcoma Glioma Penile cancer Alveolar rhabdomyosarcoma
GWAS		Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Major depressive disorder ( 23377640) Number of twin births ( 30760885)	Pneumoconiosis in silica exposure ( 24986923)
Interacting Genes		107 interacting genes: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CASP8 CBS CDK4 CEBPA CEBPE CHUK CNOT7 CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 EP300 ESR1 ESR2 FANCI FHL3 FLI1 GATA4 GLUL GRM8 GSK3B GTF2IRD1 HECTD2 HIC1 HTT IKZF5 JUN KLF3 L3MBTL2 LSM3 MAML1 MBD1 MDC1 MDM2 MITF MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRPF40A PSME3 PTK2 PTPN1 QKI RAD54L2 RBBP6 RELA SATB1 SATB2 SERBP1 SGTA SKIL SMAD1 SMAD4 SMAD7 SNAI2 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO1P1 SUMO2 SUMO3 TBP TERF2 TEX11 TP53 TP73 TRIM27 TRIM5 TRIM55 TRIM63 TSG101 UBE2I UBE2L3 YWHAZ ZNF451 ZNF76	255 interacting genes: ABL1 ABL2 ADRB2 AKT1 ANKRD17 APEX1 APP AR ARRB1 ARRB2 ATF3 ATF4 ATM ATP2A2 ATRX AURKA BAIAP2L1 BRINP1 BTK BTRC CANX CASP2 CASP3 CCAR1 CCNG1 CDC34 CDH1 CDKN2A CHEK2 CLSTN1 CLU COPS5 CREBBP CSNK2A1 CSNK2A2 CSNK2B CTBP2 CWC25 DAPK1 DAPK3 DAXX DDX24 DDX42 DHFR DLG4 DNAJB4 DYRK2 E2F1 EID1 EP300 ESR1 EZR F3 FBXO31 FHL2 FKBP1A FOXO1 G3BP2 GADD45A GCAT GLIS2 GNL3 GORAB GRK2 GSK3B GTF2E2 GYS2 H2BC21 H3-4 HCK HDAC1 HEY1 HIF1A HIPK2 HLA-DMB HMGA2 HMGN1 HNRNPK HSP90B1 IER3 IGF1R IRF1 IRF2 JMY JUN JUND KAT2B KAT5 KPNA1 LMO7 MAGEA2 MAP1LC3A MAP2 MAPKAPK2 MDM4 MED1 MKRN3 MS4A1 MTBP MYC MYD88 MYDGF NACA NAT10 NCL NGFR NOLC1 NOP53 NOTCH1 NPIPB3 NPM1 NR3C1 NUCKS1 NUMB PAK6 PBX1 PBXIP1 PDE4D PDIA3 PDLIM7 PDS5A PER2 PGAM2 PHF7 PHLDB3 PIAS1 PJA1 PKM PLK1 PML POLE POT1 PPIB PPM1D PPP1R10 PRDM2 PSMA3 PSMC5 PSMD10 PSMD4 PSME3 PTK2 RAB8A RAD23A RANBP1 RANBP2 RARA RASSF1 RB1 RBBP6 RBM38 RCHY1 RESF1 RIDA RLIM RNF10 RNF126 RNF8 RPL11 RPL22 RPL26 RPL36A RPL4 RPL5 RPS23 RPS27A RPS3 RPS5 RRM2B RRP1 RSL1D1 RUVBL2 RYBP RYR2 S100A1 S100A2 S100A4 S100A6 S100B SDHC SENP3 SESN2 SET SETD7 SETDB1 SHPK SIRT2 SIRT3 SMARCA2 SMARCA4 SMARCE1 SMG7 SORBS2 SRC SREK1 SRSF11 STK11 SUMO1 TAF1 TBP TCAP TERT TFIP11 TOP1 TP53 TP53I3 TP53RK TP73 TPR TPT1 TRAF5 TRIM13 TRIM23 TRIM27 TRIM4 TRIM9 TSG101 UBB UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2J2 UBE2K UBE2L3 UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2U UBE2Z UBE3A UBQLN4 UBTF USP15 USP2 USP7 VEGFA WRN WT1 XBP1 XIAP XPC YY1AP1 ZNF133 ZNF420
Entrez ID		8554	4193
HPRD ID		16029	01272
Ensembl ID		ENSG00000033800	ENSG00000135679
Uniprot IDs		O75925 Q1XBU8	A0A0A8KB75 A7UKX7 A7UKX8 A7UKX9 G3XA89 Q00987 Q96DS0
PDB IDs		1V66	1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2F1Y 2FOP 2GV2 2HDP 2LZG 2M86 2MPS 2RUH 2VJE 2VJF 3EQS 3G03 3IUX 3IWY 3JZK 3JZR 3JZS 3LBK 3LBL 3LNJ 3LNZ 3MQS 3TJ2 3TPX 3TU1 3V3B 3VBG 3VZV 3W69 4DIJ 4ERE 4ERF 4HBM 4HFZ 4HG7 4JV7 4JV9 4JVE 4JVR 4JWR 4MDN 4MDQ 4OAS 4OBA 4OCC 4ODE 4ODF 4OGN 4OGT 4OGV 4OQ3 4QO4 4QOC 4UD7 4UE1 4UMN 4WT2 4XXB 4ZFI 4ZGK 4ZYC 4ZYF 4ZYI 5AFG 5C5A 5HMH 5HMI 5HMK 5J7F 5J7G 5LAV 5LAW 5LAY 5LAZ 5LN2 5MNJ 5OAI 5OC8 5SWK 5TRF 5UMM 5VK0 5WTS 5XXK 5Z02 5ZXF 6AAW 6GGN 6H22 6I29 6I3S 6IM9 6KZU 6Q96 6Q9H 6Q9L 6Q9O
Enriched GO Terms of Interacting Partners?
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