ELP1 and IRF4

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ELP1	IRF4
Description		elongator complex protein 1	interferon regulatory factor 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex	Nuclear Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Cytosol Membrane
	Molecular Function	Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	TRNA Wobble Uridine Modification	Immune System Process Cytokine-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis
Pathways		HATs acetylate histones	Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Celiac disease ( 22057235 20190752) Chronic lymphocytic leukemia ( 18758461 28165464 26956414 24292274 23770605) Crohn's disease ( 26192919) Cutaneous squamous cell carcinoma ( 27424798) Eye color ( 20585627 30664655) Eye color (brightness) ( 30664655) Eye color traits ( 30166351) Facial pigmentation ( 25705849) Feeling nervous ( 29500382) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 30664655 29662168 26926045) Hair greying ( 26926045) Hair morphology traits ( 30166351) Hematology traits ( 23303382) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Limited cutaneous systemic scleroderma ( 29293537) Low tan response ( 29739929) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 27863252) Male-pattern baldness ( 29146897 27182965 28196072) Medication use (thyroid preparations) ( 31015401) Melanoma ( 28212542) Monobrow ( 27182965) Nevus count ( 30429480) Non-melanoma skin cancer ( 23548203 29739929) Progressive supranuclear palsy ( 21685912) Psoriasis ( 25903422 25574825 23143594) Rheumatoid arthritis ( 30423114 24390342) Rosacea symptom severity ( 29771307) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Tanning ( 23548203) Vitiligo ( 27723757)
Interacting Genes		25 interacting genes: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP3 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9	20 interacting genes: BATF BCL6 ELP1 ETV7 FKBP4 HOXB13 HOXC11 IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 USP4 YTHDC2
Entrez ID		8518	3662
HPRD ID		04763	03543
Ensembl ID		ENSG00000070061	ENSG00000137265
Uniprot IDs		B3KNB2 B4E3I9 F5H2T0 O95163 Q4LE38 Q8N516	Q15306
PDB IDs		5CQR	2DLL
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?