SORBS2 and SEMA6A

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SORBS2	SEMA6A
Description		sorbin and SH3 domain containing 2	semaphorin 6A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Actin Cytoskeleton Apical Plasma Membrane Z Disc Lamellipodium Perinuclear Region Of Cytoplasm	Extracellular Space Integral Component Of Plasma Membrane Integral Component Of Membrane Axon
	Molecular Function	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Structural Constituent Of Muscle	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Actin Filament Organization Notch Signaling Pathway Biological_process Cell Growth Involved In Cardiac Muscle Cell Development	Neural Crest Cell Migration Apoptotic Process Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Negative Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Neuron Migration
Pathways			Other semaphorin interactions
Drugs
Diseases
GWAS		Cardiac Troponin-T levels ( 31014085) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) Short-term memory (digit-span task) ( 30741946) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Allergic rhinitis ( 22036096) Amyotrophic lateral sclerosis ( 19451621) Blood protein levels ( 29875488) Body mass index ( 27296613) Chronotype ( 30696823) Eosinophilic esophagitis ( 25017104) High chromosomal aberration frequency (chromatid type) ( 31586183) Periodontitis (DPAL) ( 24024966) Wegener's granulomatosis ( 23740775)
Interacting Genes		37 interacting genes: ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL DLGAP1 DLGAP2 DLGAP4 EFS EGFR FAT1 FLOT1 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SYNJ1 TRAF4 VCL VPS37C WAS WASF1 YWHAE YWHAZ	6 interacting genes: EVL ITSN2 SH3RF1 SORBS1 SORBS2 UBE2I
Entrez ID		8470	57556
HPRD ID		12473	06906
Ensembl ID		ENSG00000154556	ENSG00000092421
Uniprot IDs		B7Z3D7 B7Z997 O94875	A0A0A0MQU6 Q9H2E6
PDB IDs		5VEI
Enriched GO Terms of Interacting Partners?
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