MED10 and KDM4B

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		MED10	KDM4B
Description		mediator complex subunit 10	lysine demethylase 4B
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity	Histone Demethylase Activity Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Histone H3-K9 Demethylation Oxidation-reduction Process Histone H3-K36 Demethylation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS			Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of white cells ( 27863252) Periodontitis (CDC/AAP) ( 24024966) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: ESR1 ESR2 HNF4A KDM4B MOB4 NAP1L1 PEBP1	2 interacting genes: H3-5 MED10
Entrez ID		84246	23030
HPRD ID		14680	11056
Ensembl ID		ENSG00000133398	ENSG00000127663
Uniprot IDs		Q9BTT4	A0A0C4DFL8 F5GX28 O94953
PDB IDs			4LXL 4UC4
Enriched GO Terms of Interacting Partners?
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