ULK1 and MEFV

Number of citations of the paper that reports this interaction (PubMedID 26347139)
65

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ULK1	MEFV
Description		unc-51 like autophagy activating kinase 1	MEFV innate immuity regulator, pyrin
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Membrane Axon Guanyl-nucleotide Exchange Factor Complex Phagophore Assembly Site Membrane Recycling Endosome Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane Extrinsic Component Of Autophagosome Membrane Atg1/ULK1 Kinase Complex	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Rab GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Autophagosome Assembly Protein Phosphorylation Autophagy Signal Transduction Protein Localization Regulation Of Autophagy Positive Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein Complex Assembly Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Axon Extension Autophagy Of Host Cells Involved In Interaction With Symbiont Positive Regulation Of Autophagosome Assembly	Inflammatory Response Positive Regulation Of Autophagy Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		Macroautophagy TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)	Ankylosing spondylitis ( 30946743)
Interacting Genes		23 interacting genes: ATG13 ATG9A BECN1 EXOC8 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MAPK14 MBP MEFV MUL1 NEDD4L OCLN PPP1CA PRKAA1 SDCBP SMCR8 SYNGAP1 UBC USP20	12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1
Entrez ID		8408	4210
HPRD ID		11933	02012
Ensembl ID		ENSG00000177169	ENSG00000103313
Uniprot IDs		O75385	D2DTW2 O15553
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS	2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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