CASP6 and CASP10

Number of citations of the paper that reports this interaction (PubMedID 8962078)
77

Data Source:
HPRD (in vitro)

		CASP6	CASP10
Description		caspase 6	caspase 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	Proteolysis Apoptotic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway
Pathways		Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258)	Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831)
Interacting Genes		38 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	32 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 NPTX1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP SCARB1 TNFRSF1A TRAF1 XIAP
Entrez ID		839	843
HPRD ID		03321	03458
Ensembl ID		ENSG00000138794	ENSG00000003400
Uniprot IDs		P55212	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV
Enriched GO Terms of Interacting Partners?
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