GFI1B and MEGF8

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GFI1B	MEGF8
Description		growth factor independent 1B transcriptional repressor	multiple EGF like domains 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Plasma Membrane Nuclear Matrix	Nucleus Integral Component Of Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Protein Binding Metal Ion Binding	Calcium Ion Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription, DNA-templated Multicellular Organism Development Regulation Of Gene Expression Regulation Of Hemopoiesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Embryonic Heart Tube Morphogenesis Animal Organ Morphogenesis Tissue Development Regulation Of Gene Expression Embryonic Limb Morphogenesis BMP Signaling Pathway Limb Morphogenesis Cell Migration Involved In Gastrulation Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Coronary Vasculature Development Determination Of Heart Left/right Asymmetry Determination Of Digestive Tract Left/right Asymmetry Craniofacial Suture Morphogenesis Fasciculation Of Sensory Neuron Axon
Pathways
Drugs
Diseases
GWAS		Basophil percentage of white cells ( 27863252) Cardiometabolic and hematological traits ( 27668658) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252) Myeloid white cell count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		71 interacting genes: ACTN1 AGRN AJUBA ANKS3 ATXN2 BABAM2 BECN1 BEGAIN BEND5 BRCA1 CCDC136 CCDC85B CENPB CENPJ COPS5 DNAJA3 DTNA DZANK1 EFEMP1 EFEMP2 EGFL7 FBLN1 FBLN5 GPAT4 GRIP2 GRN HECW1 HGS HNRNPK HSPG2 IFFO1 JAG2 KALRN KIF17 LAMB1 LTBP4 LZTS2 MATR3 MEGF6 MEGF8 MID2 MON1A MYH14 NELL1 NELL2 NOTCH1 NSMF PDE4DIP PDLIM5 PDZD4 PHC2 PICK1 PSMA3 RAB11FIP4 RCHY1 RINT1 RNF31 RUNDC3A TAF1 TLE5 TMF1 TNS2 TRAF1 TRIM27 TRIP6 TSPYL2 TXNDC11 USHBP1 VSNL1 ZNRD1 ZNRF3	3 interacting genes: ATN1 CACNA1A GFI1B
Entrez ID		8328	1954
HPRD ID		05088	10370
Ensembl ID		ENSG00000165702	ENSG00000105429
Uniprot IDs		A0A024R8F3 Q5VTD9	Q7Z7M0
PDB IDs
Enriched GO Terms of Interacting Partners?
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