BRAP and PHLPP1

Number of citations of the paper that reports this interaction (PubMedID 25820252)
4

Data Source:
BioGRID (two hybrid, pull down)

		BRAP	PHLPP1
Description		BRCA1 associated protein	PH domain and leucine rich repeat protein phosphatase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol Nuclear Membrane	Cytoplasm Cytosol Plasma Membrane Nuclear Membrane
	Molecular Function	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination	Regulation Of T Cell Anergy Protein Dephosphorylation Apoptotic Process Entrainment Of Circadian Clock Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Regulation Of Protein Kinase C Signaling Regulation Of P38MAPK Cascade
Pathways		RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Negative regulation of the PI3K/AKT network
Drugs
Diseases
GWAS		Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence ( 31591379) Alcohol dependence symptom count ( 29460428) Alcohol use disorder (consumption score) ( 30940813) Asthma ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 29875488) Body mass index ( 26426971 25673413) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Coffee consumption ( 29367735) Colorectal cancer ( 26151821) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407) Esophageal cancer ( 19698717) Gastroesophageal reflux disease ( 31527586) Hematological and biochemical traits ( 20139978) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) LDL cholesterol ( 24097068 20686565) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25854761 28537254) Response to alcohol consumption (flushing response) ( 29460428) Serum folate levels ( 29953918) Serum uric acid levels ( 29124443) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		40 interacting genes: AKAP3 APOA1 ATMIN BRCA1 BRK1 CCDC105 CCDC30 CDC14A CENPF CNKSR1 DDB1 DNMT1 FAM184A FBXO2 HMG20A HRAS KSR1 LINC00852 NUMA1 PHLPP1 RBM12 SHCBP1L SKP2 SMARCE1 SYNE2 TANC2 TEX35 TRIM41 TRIM55 TRIM8 UBB UBC UBE2D2 UBE2H UBE2L3 USP15 USP4 ZNF382 ZNF479 ZNF521	6 interacting genes: BRAP CSNK1A1 GSK3B SLC9A3R1 SUGT1 WDR48
Entrez ID		8315	23239
HPRD ID		05405	15145
Ensembl ID		ENSG00000089234	ENSG00000081913
Uniprot IDs		Q59H81 Q7Z569	O60346
PDB IDs
Enriched GO Terms of Interacting Partners?
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