PICALM and EHD2

Number of citations of the paper that reports this interaction (PubMedID 15182197)
16

Data Source:
HPRD (in vitro, in vivo)

		PICALM	EHD2
Description		phosphatidylinositol binding clathrin assembly protein	EH domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cell Surface Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Intrinsic Component Of Membrane Vesicle Presynaptic Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Endosome To Plasma Membrane Transport Vesicle Neurofibrillary Tangle Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Nucleus Cytosol Plasma Membrane Caveola Endosome Membrane Microtubule Cytoskeleton Extrinsic Component Of Membrane Intercellular Bridge Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	SNARE Binding Amyloid-beta Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Rab GTPase Binding Clathrin Binding Clathrin Heavy Chain Binding Cadherin Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding	Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Vesicle Budding From Membrane Axonogenesis Learning Or Memory Negative Regulation Of Gene Expression Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Cargo Loading Into Vesicle Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Dendrite Morphogenesis Iron Ion Homeostasis Membrane Organization Protein-containing Complex Assembly Clathrin-dependent Endocytosis Modulation Of Age-related Behavioral Decline Regulation Of Vesicle Size Membrane Bending Amyloid-beta Clearance By Transcytosis Positive Regulation Of Neuron Death Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Clathrin-coated Pit Assembly Negative Regulation Of Protein Localization To Cell Surface	Endocytosis Blood Coagulation Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Myoblast Fusion Positive Regulation Of Endocytic Recycling
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 19734902 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Chronic obstructive pulmonary disease ( 30804561) Family history of Alzheimer's disease ( 30617256) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Platelet count ( 27863252) Tourette syndrome ( 22889924)
Interacting Genes		14 interacting genes: AP2A1 CASP3 CASP8 CLTC CLTCL1 CRX DDIT3 EHD2 FCHO1 ITSN1 PELI2 PLCG1 RBPMS SMURF1	13 interacting genes: AP1M1 AP1M2 AP2M1 BPGM DDX56 EHBP1 PICALM PICK1 RBSN SLC2A4 SPATA24 TAGLN2 TBC1D23
Entrez ID		8301	30846
HPRD ID		04320	10434
Ensembl ID		ENSG00000073921	ENSG00000024422
Uniprot IDs		A0A024R5L7 A0A024R5P1 Q13492	A0A024R0S6 Q9NZN4
PDB IDs
Enriched GO Terms of Interacting Partners?
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