SMC1A and SMC3

Number of citations of the paper that reports this interaction (PubMedID 11076961)
163

Data Source:
HPRD (in vivo)

		SMC1A	SMC3
Description		structural maintenance of chromosomes 1A	structural maintenance of chromosomes 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Mitotic Spindle Pole	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	Chromatin Binding RNA Binding Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding
	Biological Process	Mitotic Sister Chromatid Segregation DNA Repair Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Regulation Of Mitotic Spindle Assembly	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Regulation Of Mitotic Spindle Assembly
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)	Cornelia de Lange syndrome (CdLS)
GWAS		Bipolar disorder ( 31043756)	Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: ATM BLM BRCA1 ESR1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3	17 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1
Entrez ID		8243	9126
HPRD ID		02077	05829
Ensembl ID		ENSG00000072501	ENSG00000108055
Uniprot IDs		A0A384MR33 G8JLG1 Q14683 Q68EN4	Q9UQE7
PDB IDs
Enriched GO Terms of Interacting Partners?
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