NCOA3 and PPARA

Number of citations of the paper that reports this interaction (PubMedID 15888456)
20

Data Source:
BioGRID (pull down)

		NCOA3	PPARA
Description		nuclear receptor coactivator 3	peroxisome proliferator activated receptor alpha
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Complex Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Androgen Receptor Binding Disordered Domain Specific Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Fatty Acid Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Nuclear Receptor Transcription Coactivator Activity Ubiquitin Conjugating Enzyme Binding Signaling Receptor Activity Sequence-specific DNA Binding Protein-containing Complex Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Positive Regulation Of Gene Expression Histone Acetylation Androgen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Receptor Transactivation Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Regulation Of RNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Multicellular Organism Development Heart Development Epidermis Development Hormone-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Fatty Acid Transport Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Response To Nutrient Levels Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Response To Lipid Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Inflammatory Response Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Enamel Mineralization Cellular Response To Lipid Negative Regulation Of Neuron Death Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors
Drugs			Alpha-Linolenic Acid Icosapent Troglitazone Valproic Acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Pioglitazone Gemfibrozil Bezafibrate Prasterone N,N-bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic Acid Resveratrol Phthalic Acid Lauric Acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglixane Elafibranor GW-501516 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID Indeglitazar Myristic acid Aleglitazar Clinofibrate Soybean oil Omega-3 fatty acids Myrrh Leukotriene B4 Fenofibric acid
Diseases
GWAS		Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)	Cholesterol, total ( 24097068) CTACK levels ( 27989323) Impulsivity (motor) ( 30718321) LDL cholesterol ( 24097068) Resting-state electroencephalogram vigilance ( 29703947) Type 2 diabetes ( 31049640) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		81 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4-16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SMARCE1 SPOP SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ	46 interacting genes: AIP AKAP13 BCL2 CDC34 CDK3 CEP350 CHD9 DAP3 DUT EP300 FABP1 FOXA3 GADD45A GADD45B GADD45G HELZ2 HSP90AA1 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H3 NRBF2 NRIP1 PAQR3 PIK3R3 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SIRT1 STAC3 TNP1 UBE2I
Entrez ID		8202	5465
HPRD ID		03570	01369
Ensembl ID		ENSG00000124151	ENSG00000186951
Uniprot IDs		Q59EE8 Q9Y6Q9	F1D8S4 Q07869
PDB IDs		1KBH 3L3X 3L3Z 6ES7	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK
Enriched GO Terms of Interacting Partners?
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